Altered expression pattern of testican-1 mRNA after brain injury

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Analysis of functional pathways altered after mild traumatic brain injury.

Concussive injury (or mild traumatic brain injury; mTBI) can exhibit features of focal or diffuse injury patterns. We compared and contrasted the cellular and molecular responses after mild controlled cortical impact (mCCI; a focal injury) or fluid percussion injury (FPI; a diffuse injury) in rats. The rationale for this comparative analysis was to investigate the brain's response to mild diffu...

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increased expression of glial cell line-derived neurotrophic factor in rat brain after traumatic brain injury

glial cell line-derived neurotrophic factor (gdnf) plays important roles not only for the differentiation of neurons during normal development but also for the survival and recovery of many populations of mature neurons. the effect of traumatic brain injury (tbi) on the expression of gdnf is currently unknown. to determine if there is alteration in gdnf after tbi we examined the effect of contr...

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Impact of STAT/SOCS mRNA Expression Levels after Major Injury

BACKGROUND Fulminant changes in cytokine receptor signalling might provoke severe pathological alterations after multiple trauma. The aim of this study was to evaluate the posttraumatic imbalance of the innate immune system with a special focus on the STAT/SOCS family. METHODS 20 polytraumatized patients were included. Blood samples were drawn 0 h-72 h after trauma; mRNA expression profiles o...

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ژورنال

عنوان ژورنال: Biomedical Research

سال: 2011

ISSN: 1880-313X,0388-6107

DOI: 10.2220/biomedres.32.373